Stake is an item that is used to kill vampyre during  the Vampire Slayer quest. It can deal over 4000 damage on the target vampire, making it much easier (or possible) to complete the quest


You can get it by giving Dr. Harlow a glass of beer which you can get in Faladors pub. Dr. Harlow can be found inside ¨The Blue Moon In¨ which is a pub in Varrock.